Prothrombin Precursor Antibody (Antibody)
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SynName: Monoclonal Prothrombin precursor; Anti-Prothrombin precursor; F2coagulation factor II; F2_BB; FII; Prothrombin; prothrombin B-chain; prothrombin precursorPT; RP23-176N9.4; RPRGL2; serine protease; silk fibroin 2; THPH1; thrombinthrombin B chain variant 1; vitamin K dependent serine proteaseClonality: Monoclonal; *Isotype: IgG2b kappa; *Clone: 28H5; *Source: Mouse; *Reactivity: HumanTested: ELISA (EIA), Western Blot (WB); *AppNotes: WB: 1:1000Purity: Prothrombin precursor antibody was purified by ammonium sulfate precipitationStorage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cyclesFREE-8GB-USBDrive for this item. Item is for research use. NOT for diagnostic/therapeutic procedure.*Form: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol; *Biological Significance: Prothrombin precursor is synthesized in liver as a precursor of prothrombin containing a signal sequence and a propeptide domain at the N-terminus. Before its secretion into plasma, this precursor undergoes several posttranslational modifications, including removal of signal sequence and propeptide domains, glycosylation, and gamma-glutamyl-carboxylation reaction. Prothrombin, cleaved by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium, is converted to thrombin which converts fibrinogen into fibrin which in turn strengthens a protective clot. Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin (e.g. hypoprothrombinemia) have been described.; *Immunogen: Prothrombin precursor antibody was raised in Mouse using a protein purified from Human plasma as the immunogen; *Description: Mouse monoclonal Prothrombin precursor antibody Looking for more products about reactions to b complex vitamins .
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